Dan Winer MD, FRCP(C)
Assistant Professor
daniel winer

Contact Info

T: (416) 581-7533
Website

Location

University Health Network
Toronto General Research Institute

Accepting

Grad Students Must First Apply Through Department

Appointments

Scientist, Division of Advanced Diagnostics - Metabolism Toronto General Research Institute
Endocrine Pathologist
Assistant Professor, Department of Laboratory Medicine and Pathobiology

Research Interests

Adaptive Immunity, Innate Immunity

The goal of our laboratory is to better understand how the immune system influences physiological processes and contributes to disease, with the aim of using this information to develop new translational diagnostics and therapeutics, including preventative vaccination strategies.

Inflammation and adaptive Immunity in insulin resistance and type 2 diabetes.

Our primary research focus is to elucidate immune mediated pathways governing obesity related insulin resistance. Obesity and its major complications, including insulin resistance, are a major global cause of morbidity and mortality, and have reached epidemic proportions. Evidence is mounting that a significant contributing cause of insulin resistance is chronic inflammation in visceral adipose tissue (VAT). This inflammation was initially thought to be driven solely by macrophages of the innate immune system attracted to dying adipocytes in fat. Recently, in collaboration with the Hospital for Sick Children and Stanford University, we have demonstrated that the adaptive immune system, including T cells, B cells and the antibodies they produce, play a significant and active role in regulating this process. This work has introduced a new " autoimmune" component to obesity related insulin resistance, and has led to new ways in thinking about metabolic disease. We continue to investigate immune mediated mechanisms in obesity and diabetes with the aim of translating our findings to help the many people afflicted by these diseases.

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