PAMELA S. OHASHI, Ph.D., FRSC

Tolerance, autoimmunity, immune surveillance, apoptosis
 

The Campbell Family Institute for Breast Cancer Research Ontario Cancer Institute University Health Network 620 University Avenue Toronto, ON M5G 2C1 Tel: 416-946-2357 Fax: 416-946-2086 E-mail: pohashi@uhnres.utoronto.ca

T cell selection and immunological tolerance

RESEARCH INTERESTS

My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo.  We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate.  In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.

Our recent studies have examined novel ways that dendritic cells are
programmed to influence T cell function in vivo.   In addition we are
focussed on how the tissue or tumor microenvironment can have a significant impact on T cell responses.

Importantly, my interests have also expanded to establishing an immune therapy platform.  My group has developed the ability to grow tumor infiltrating T cells and characterize their properties.  We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.

LAB MEMBERS

Students
Dilan Dissanayake
Dylan Johnson
Heather MacGregor
Charles Tran

Post doctoral Fellows
Sarah Crome
Evan Lind
Sara Hamilton

Senior Associates
Kiichi Murakami
Linh Nguyen

For Recent publications, please visit PubMed