Marc Jeschke MD, PhD, FACS, FRCSC
Professor
marc jeschke
Contact Info
T: (416) 480-6703
F: (416) 480-6763
Website
Location
Sunnybrook Research Institute
2075 Bayview Avenue, Room D704
Toronto, ON, M4N3M5
Accepting
Grad Students Must First Apply Through Department
Appointments
Senior Scientist, Sunnybrook Research Institute
Research Interests
Inflammation, Metabolism

Dr. Marc G Jeschke is a Senior Scientist and the Director of the Ross Tilley Burn Center at Sunnybrook Health Science Center. He is a Professor in the Department of Surgery, Department of Immunology and the Institute of Medical Science. The focus of his work is translational research with the employment of basic and clinical research in burns. Within his laboratory he has two active groups, one is focusing on Skin stem cells and skin regeneration and the other is focusing on immune-metabolism aspects of burn. In the group of Stem cell and Skin Regeneration, the group employs different in vitro and in vivo approaches to enlighten the process of healing post injury including immune and inflammatory mediators affecting stem cells. Finding new sources of stem cells and their combination together with an optimal approach to print the cells in a 3D format is the focus of the group.

The Immunometabolism group is trying to identify agents that mediate profound metabolic alterations and understanding how these agents function in burn patients. In particular, the group is interested in addressing the role of the communication between the different metabolic organs (mainly liver and adipose tissue) and inflammatory cells in the installation of hypermetabolism and its complications. Additionally the group looks at glucose and fat as immune mediators and their pro-inflammatory or anti-inflammatory role.

Publications and Awards

Recent Publications

  1. Jeschke MG, Herndon DN (2014) Burns in children: standard and new treatments. Lancet 383: 1168- 1178.
  2. Xiu F, Catapano M, Diao L, Stanojcic M, Jeschke MG. Prolonged ER Stressed-Hepatocytes Drives an Alternative Macrophage Polarization. Shock. 2015 May. 2015 May 4. [Epub ahead of print].
  3. Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, et al. (2014) Effect of human Wharton's jelly mesenchymal stem cell paracrine signaling on keloid fibroblasts. Stem Cells Transl Med 3: 299-307.
  4. Jeschke MG, Gauglitz GG, Finnerty CC, Kraft R, Mlcak RP, et al. (2014) Survivors versus nonsurvivors postburn: differences in inflammatory and hypermetabolic trajectories. Ann Surg 259: 814-823.
  5. Chen P, Stanojcic M, Jeschke MG. Differences between murine and human sepsis. Surg Clin North Am. 2014 Dec;94(6):1135-49. Review.
  6. Kraft R, Herndon DN, Finnerty CC, Cox RA, Song J, Jeschke MG. Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury - A Clinical Study. Shock. 2014 Nov. 2014 Nov 8. [Epub ahead of print].
  7. Bogdanovic E, Kraus N, Patsouris D, Diao L, Wang V, Abdullahi A, Jeschke MG. Endoplasmic reticulum stress in adipose tissue augments lipolysis. J Cell Mol Med. 2014 Nov. 2014 Nov 8. doi: 10.1111/jcmm.12384. [Epub ahead of print].
  8. Stanojcic M, Chen P, Harrison RA, Wang V, Antonyshyn J, Zúñiga-Pflücker JC, Jeschke MG. Leukocyte Infiltration and Activation of the NLRP3 Inflammasome in White Adipose Tissue Following Thermal Injury. Crit Care Med. 2014 Mar. 2014 Feb 26. [Epub ahead of print].
  9. Kraft R, Herndon DN, Al-Mousawi AM, Williams FN, Finnerty CC, et al. (2012) Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. Lancet 379: 1013-1021.
  10. Xiu F, Jeschke MG. Perturbed mononuclear phagocyte system in severely burned and septic patients. Shock. 2013 Jul. 2013 Aug;40(2):81-8. doi: 10.1097/SHK.0b013e318299f774.
  11. Xiu F, Stanojcic M,Jeschke MG. Norepinephrine Inhibits Macrophage Migration by Decreasing CCR2 Expression. PLoS One. 2013 Jun. 2013 Jul 2;8(7):e69167. doi: 10.1371/journal.pone.0069167. Print 2013.