Dr Marc de Perrot's research focuses on innovative approaches to integrate immunotherapy in the treatment of mesothelioma. He and his colleague Dr John Cho were the first to implement the concept of Surgery for Mesothelioma After Radiation Therapy (SMART approach) in clinical practice. Some of his projects investigates the impact of radiation and surgery on the immune system to use SMART as a platform for immunotherapy. Other projects investigate the role of the immune system in the development of mesothelioma after asbestos exposure in order to discover biomarkers to identify individuals at risk of mesothelioma. His laboratory has developed multiple animal models to study the development and treatment of mesothelioma.
His work also focuses on the role of the immune system in the development of pulmonary hypertension, particularly in the context of pulmonary emboli. The surgical treatment of CTEPH with pulmonary thromboendarterectomy (PTE) performed at UHN provides unique opportunities to analyze this condition in his laboratory