Olga L. Rojas

Olga L. Rojas MD, PhD
Assistant Professor
Contact Info
T: (416) 603-5800 2120
F: (416) 603-6274
Website
Location
University Health Network
Krembil Discovery Tower
60 Leonard Ave, Room 7KD411
Toronto, ON, M2T 0S8
Appointment Status Primary
Accepting
Grad Students Must First Apply Through Department
Undergraduate Students
Research Interests
Adaptive Immunity, Autoimmunity, Infectious Diseases, B cells, Microbiota

Recent research by Dr. Rojas, published in Cell(link is external), uncovered the role of intestinal Plasma cells in inflammation during neuroinflammation. These findings revealed that a subset of microbiome-specific IgA Plasma cells is key to fighting Experimental Acute Encephalomyelitis (EAE), a mouse model for Multiple Sclerosis (MS). These IgA-producing plasma cells can travel from the intestines to the central nervous system where they are found to suppress brain inflammation during MS flare-ups.

Currently, Dr. Rojas is interested in understanding the role of mucosal immune cells as a key intermediate of the gut-brain axis. Central to this question is understanding how intestinal immune cells can directly (by migration) or indirectly (by cytokines, chemokines) impact pathogenic processes in the brain in neurodegenerative disorders such as Alzheimer disease and Parkinson disease.

Publications and Awards

View PubMed search of this faculty member's recent publications.