Minna Woo

Minna Woo MD, FRCPC, PhD
Minna Woo
Contact Info
T: (416) 581-7531
F: (416) 581-7880
University Health Network
TGHRI at the MaRS Ctre, TMDT
101 College St, 10th floor, Rm 10-363
Toronto, ON, M5G 1L7
Grad Students Must First Apply Through Department
Scientist, Toronto General Hospital Research Institute
Research Interests
Inflammation, Signal transduction in diabetes pathogenesis, Insulin resistance, Diabetes-related atherosclerosis, Cancer

The major research focus in the Woo laboratory is to elucidate molecular mechanisms that determine pathogenesis of insulin resistance and type 2 diabetes, which are well known to increase the risk of cardiovascular disease and cancer. We are investigating many of the fundamental genes that are involved in cell survival and differentiation, in particular, tumour suppressors and oncogenes. Many of these fundamental genes have essential physiological roles in metabolic tissues such as liver, muscle, adipose tissue, and the pancreatic islets. The roles of many of the fundamental genes are highly context dependent and are specific for the tissue in which they function. Using genetically engineered mice, we examine the whole body physiology as well as take biological, biochemical and molecular approaches to define physiological roles in specific tissues, in addition to defining its potential pathogenic role in diabetes. We also study the role of insulin resistance in cancer and cardiovascular diseases. These approaches to clarify tissue-specific molecular mechanisms have wide implications for better understanding and treatment of both diabetes as well as its relationships to cancer and cardiovascular disease.

Publications and Awards

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Honours and Awards

Canada Research Chair in Diabetes Pathogenesis
Member Elect of the American Society for Clinical Investigation